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. 2020 Sep 3;5(17):e138949. doi: 10.1172/jci.insight.138949

Figure 2. Burn patients who develop keloids have prior indications of altered glucose metabolism.

Figure 2

(A) GLUT1 gene expression in burn and normal skin samples obtained from burn patients before the development of keloids indicates higher expression compared with typical values seen in nonkeloid patients (≥ 2 SDs above mean). Similarly, keloids exhibited increased Glut1 staining. (B) Immunohistochemical staining for Glut1 in skin from keloid patients indicates more Glut1+ cells in basal epidermal and dermal layers compared with nonkeloid counterparts (normal skin, top panel; burn skin 7–10 days after burn, bottom panel). Individual data points (X) denote gene expression values for individual patients. Values are presented as mean ± SEM. Experiments were conducted twice. One-way ANOVA; **P < 0.01 burn versus normal.