Figure 3. Complement activation is associated with increased PGD severity within the first 24 hours of lung transplantation.

Levels of sC4d (A) and sC5b-9 (B) were elevated in subjects who developed PGD compared with those who did not. Note that there were inherent differences in clinical practices at the 2 centers, including the variability in the volume of fluid instilled into the lung, as well as the return, which partially explain the differences in the levels of sC4d and sC5b-9 when compared with Figure 2. Rank sum tests of comparison (Mann-Whitney U test). WUSM cohort, n = 80.