Neil1−/− mice are more sensitive to IR exposure. (A) A diagram of the experimental design. (B) Effects of gamma irradiation on the weight loss of WT or Neil1−/− mice. n = 12 (WT sham), 15 (WT IR), 10 (Neil1−/− sham), 13 (Neil1−/− IR) mice. Data shown are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. Pathways in the hippocampus of IR- and sham-treated mice of WT or Neil1−/− were compared. We divided the pathways into metabolism pathways (C), immune-related pathways (D), and neuronal-related pathways (E).