Fig. 7.
Neil1−/− mice show an impaired response to IR compare to WT mice in the behavioral tests. Effects of IR on total distance(A) and time spent in the center (B) in the open field test, the percent of spent time (C) in open arms in elevated plus maze, the exploration time (D) and the percent of exploration time (E) in the novel object recognition test, and the freezing time (F) in context fear conditioning test. Data shown are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. n = 12 (WT sham), 15 (WT IR), 10 (Neil1−/− sham), 13 (Neil1−/− IR) mice.