TABLE 1.
Distribution of ACE gene polymorphism of pre- and post-menopause groups and the Hardy-Weinberg equilibrium.
| Groups |
Proportions of phenotype |
Proportions of D/I allele |
χ2 (p) | |||
| DD | DI | II | D | I | ||
| Pre-menopause (n = 155) | 10.32% (n = 16) | 47.74% (n = 74) | 41.94% (n = 65) | 34.19% (n = 106) | 65.81% (n = 204) | 0.259 (0.879) |
| Post-menopause (n = 236) | 12.71% (n = 30) | 46.19% (n = 109) | 41.10% (n = 97) | 35.81% (n = 169) | 64.19% (n = 303) | 0.003 (0.999) |
| Pre vs. post χ2 (p) | 0.514 (0.473) | 0.091 (0.763) | 0.027 (0.870) | 0.115 (0.735) | 0.115 (0.735) | |
A chi-square (χ2) test was used for genotype distribution. DD, homozygous deletion; DI, DI heterozygote; II, homozygous insertion; D/I, deletion/insertion; χ2, chi-square statistic. Pre vs. Post, comparison of pre- and post-menopausal women.