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. 2020 Sep 16;10:544789. doi: 10.3389/fonc.2020.544789

Figure 2.

Figure 2

Comparison of the gene expression profile with immune scores and stromal scores in malignant pleural mesothelioma [Gene Expression Omnibus (GEO) database]. Heatmaps were drawn based on the average linkage method and Pearson distance measurement method. Genes with higher expression are shown in red, genes with lower expression are shown in green, and genes with mean expression level are shown in black. (A) Heatmap of the differentially expressed genes (DEGs) of stromal scores of the top half (high score) vs. bottom half (low score). False discovery rate (FDR) < 0.05, fold change ≥ 1.5. (B) Heatmap of the DEGs of immune scores of the top half (high score) vs. bottom half (low score). FDR < 0.05, fold change ≥ 1.5. (C) Venn diagrams showing the number of common DEGs in the stromal and immune score groups. (D–G) FDR of Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analysis was acquired from DAVID functional annotation tool. p < 0.05.