Table 1.
The information for the genes significant in MPM overall survival identified in TCGA.
| Gene | Official full name | Related pathway | p-value | Method |
|---|---|---|---|---|
| NT5E | 5′-nucleotidase ecto | HIF-1-alpha transcription factor network | 8.60E-06 | Wilcoxon |
| ETS1 | ETS proto-oncogene 1, transcription factor | AP-1 transcription factor network;C-MYB transcription factor network; BCR signaling pathway; HIF-1-alpha transcription factor network; HIF-2-alpha transcription factor network; IL4-mediated signaling events; Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | 0.00249 | Wilcoxon |
| C16orf54 | Chromosome 16 open reading frame 54 | None reported | 0.00926 | Wilcoxon |
| WIPF1 | WAS/WASL interacting protein family member 1 | Fc-epsilon receptor I signaling in mast cells | 0.00079 | Wilcoxon |
| FLI1 | Fli-1 proto-oncogene, ETS transcription factor | DNA-binding transcription activator activity | 0.00102 | Wilcoxon |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6 | CDC42 signaling events | 1.00E-10 | Wilcoxon |
| HLA-DRA | Major histocompatibility complex, class II, DR alpha | IL12 signaling mediated by STAT4; IL12 signaling mediated by STAT4; CXCR4-mediated signaling events; TCR signaling in naïve CD4+ T cells; Cytokines and Inflammatory Response | 0.00315 | Wilcoxon |
| PRKCH | Protein kinase C eta | Calcium Regulation in the Cardiac Cell; G Protein Signaling Pathways; Wnt Signaling Pathway and Pluripotency | 2.90E-09 | Wilcoxon |
| C5AR1 | Complement C5a receptor 1 | Immune System; G alpha (i) signaling events; Class A/1 (Rhodopsin-like receptors) | 0.00019 | Wilcoxon |
| SPATA13 | Spermatogenesis associated 13 | Regulation of CDC42 activity; Regulation of RAC1 activity | 4.80E-07 | Wilcoxon |
| RCAN3 | RCAN family member 3 | None reported | 6.90E-10 | Wilcoxon |
| NAPSB | Napsin B aspartic peptidase, pseudogene | None reported | 1.90E-07 | Wilcoxon |
| SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Cytokine Signaling in Immune system; Immune System; Interferon Signaling; Interferon alpha/beta signaling; Metabolism | 0.00014 | Wilcoxon |
| STX11 | Syntaxin 11 | None reported | 3.10E-08 | Wilcoxon |
The p-value is for the differences in the expression of this gene in the GEO database. Genes in bold is also essential to in protein interaction analysis.