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. 2020 Sep 17;5(18):e137926. doi: 10.1172/jci.insight.137926

Figure 2. Tregs at the materno-fetal interface are bona fide Tregs with suppressive capacity.

Figure 2

(A–D) Suppression assay assessing cytokine production of IL-2 (A), IFN-γ (B), TNF-α (C), and IL-10 (D) by anti-CD3–stimulated (or unstimulated) healthy CD4+ T cells in the supernatant by multiplex immunoassay after 4 days of coculture with healthy donor bTregs, maternal bTregs, or uTregs at a 1:8, 1:4, and 1:2 ratios. Data represent median with interquartile range. n = 4 donors, but not every condition could be measured for each donor due to limited availability of material. Therefore, some conditions contain data from 3 donors.