Table 1:
LncRNAs and their biological effects in the vascular system.
| LncRNA | Cell Type | Phenotype | Putative human Ortholog | Ref. # |
|---|---|---|---|---|
| Giver | VSMC | Inflammation, oxidative stress, proliferation and hypertension | Yes | [15] |
| Lnc–Ang362 | VSMC | Proliferation | Unknown | [18] |
| H19 | VSMC | Abdominal aortic aneurysm | Yes | [19] |
| NEAT1 | VSMC | VSMC phenotypic switching | Yes | [16] |
| SMILR | VSMC | VSMC proliferation and cell cycle progression | Yes | [17] |
| SENCR | HUVEC | Stabilization of EC adherens junctions | Yes | [27] |
| LEENE | HUVEC | eNOS regulation and endothelial homeostasis | Yes | [28] |
| GATA6–AS | HUVEC | Regulates EC gene expression | Yes | [30] |
| ANRIL | HUVEC | EC phenotype | Yes | [31] |
| AF131217.1 | HUVEC | Inflammation | Yes | [32] |
| Dnm3os | Monocytes/macrophages | Inflammatory gene expression and phagocytosis | Yes | [36] |
| E330013P06 | Monocytes/macrophages | Modified LDL uptake and inflammatory gene expression | Yes | [37] |
| NTT | Monocytes | Monocyte and macrophage differentiation | Yes | [38] |
| MALAT1 | Macrophages | Regulates inflammation and promotes atherosclerosis | Yes | [39] |
| NEAT1 | Macrophages | Inflammasome activation | Yes | [40] |
| MeXis | Macrophages | Cholesterol efflux and atherosclerosis | Yes | [41] |
| CHROME | Hepatocytes/macrophages | Cholesterol homeostasis | Yes | [42] |
VSMC = vascular smooth muscle cells; HUVEC = human umbilical vein endothelial cells; EC = endothelial cells. This list represents a selection from recent studies, but does not cover all published studies.