Table 2.
Survival outcomes based on adjuvant therapy (N = 1,074)
| Characteristic | No. | Recurrence | Cervical cancer death | ||
|---|---|---|---|---|---|
| Adjusted HR (95% CI) | p value | Adjusted HR (95% CI) | p value | ||
| Adjuvant type | |||||
| CCRT | 502 | 1 | 1 | ||
| RT alone | 253 | 18.17 (0.84–1.62) | 0.35 | 1.20 (0.81–1.78) | 0.35 |
| Chemo alone | 319 | 0.95 (0.70–1.28) | 0.72 | 0.96 (0.67–1.38) | 0.83 |
| Age (continuous) | 1,074 | 0.99 (0.98–0.99) | 0.011 | 0.98 (0.97–0.99) | 0.003 |
| Histology | |||||
| SCC | 753 | 1 | 1 | ||
| Non-SCC | 321 | 2.23 (1.71–2.91) | <0.001 | 2.44 (1.77–3.35) | <0.001 |
| Parametrium | |||||
| Not involved | 638 | 1 | 1 | ||
| Involved | 436 | 1.95 (1.49–2.56) | <0.001 | 1.80 (1.29–2.50) | <0.001 |
| Deep stromal invasion | |||||
| No | 181 | 1 | 1 | ||
| Yes | 772 | 1.44 (0.95–2.20) | 0.09 | 1.63 (0.95–2.77) | 0.07 |
| Tumor size | |||||
| ≤4.0 cm | 640 | 1 | 1 | ||
| >4.0 cm | 393 | 1.09 (0.84–1.40) | 0.52 | 1.03 (0.76–1.40) | 0.86 |
| LVSI | |||||
| Not present | 124 | 1 | 1 | ||
| Present | 903 | 1.60 (0.94–2.72) | 0.08 | 1.42 (0.75–2.68) | 0.28 |
| Uterine corpus | |||||
| Not involved | 822 | 1 | 1 | ||
| Involved | 235 | 1.10 (0.82–1.47) | 0.54 | 1.35 (0.96–1.91) | 0.09 |
| Ovary | |||||
| Not involved | 1006 | 1 | 1 | ||
| Involved | 34 | 1.87 (1.08–3.26) | 0.027 | 1.82 (0.92–3.57) | 0.09 |
| Peritoneal cytology | |||||
| No malignancy | 549 | 1 | 1 | ||
| Malignancy present | 55 | 1.49 (0.93–2.38) | 0.10 | 0.91 (0.49–1.70) | 0.77 |
| Not examined | 470 | 1.13 (0.87–1.47) | 0.37 | 1.04 (0.75–1.43) | 0.82 |
| Pelvic LNR (continuous) | 1,048 | 1.03 (1.02–1.03) | <0.001 | 1.03 (1.02–1.03) | <0.001 |
| Para-aortic lymph nodes | |||||
| Not involved | 193 | 1 | 1 | ||
| Involved | 71 | 1.13 (0.65–1.97) | 0.68 | 0.93 (0.47–1.86) | 0.85 |
| Not examined | 810 | 1.12 (0.79–1.59) | 0.51 | 1.03 (0.68–1.57) | 0.90 |
An association of adjuvant treatment type and survival outcome was adjusted by a priori survival factors in Cox proportional-hazards regression models. All covariates in this table are entered in the final model. The ratio of event number per the number of covariates was ≥10 indicating the absence of overfitting in the multivariate model.
Abbreviations: HR, hazard ratio; CI, confidence interval; CCRT, concurrent chemoradiotherapy; RT, radiotherapy; SCC, squamous cell carcinoma; LVSI, lymphovascular space invasion; LNR, lymph node ratio.