Table 3.
Recurrence patterns based on adjuvant therapy (N = 1,074)
| Characteristic | No. | Local recurrence | Distant recurrence | ||
|---|---|---|---|---|---|
| Adjusted HR (95% CI) | p value | Adjusted HR (95% CI) | p value | ||
| Adjuvant type | |||||
| CCRT | 502 | 1 | 1 | ||
| RT alone | 253 | 1.41 (0.86–2.30) | 0.17 | 1.16 (0.79–1.71) | 0.44 |
| Chemo alone | 319 | 2.03 (1.34–3.08) | 0.001 | 0.47 (0.31–0.71) | <0.001 |
| Age (continuous) | 1,074 | 0.98 (0.96–0.99) | 0.005 | 0.99 (0.98–1.01) | 0.21 |
| Histology | |||||
| SCC | 753 | 1 | 1 | ||
| Non-SCC | 321 | 2.04 (1.40–2.97) | <0.001 | 1.91 (1.37–2.67) | <0.001 |
| Parametrium | |||||
| Not involved | 638 | 1 | 1 | ||
| Involved | 436 | 2.53 (1.72–3.74) | <0.001 | 1.53 (1.09–2.14) | 0.015 |
| Deep stromal invasion | |||||
| No | 181 | 1 | 1 | ||
| Yes | 772 | 1.31 (0.70–2.43) | 0.39 | 1.43 (0.86–2.39) | 0.17 |
| Tumor size | |||||
| ≤4.0 cm | 640 | 1 | 1 | ||
| >4.0 cm | 393 | 1.06 (0.75–1.51) | 0.75 | 1.16 (0.84–1.59) | 0.37 |
| LVSI | |||||
| Not present | 124 | 1 | 1 | ||
| Present | 903 | 1.59 (0.76–3.34) | 0.22 | 1.43 (0.76–2.72) | 0.27 |
| Uterine corpus | |||||
| Not involved | 822 | 1 | 1 | ||
| Involved | 235 | 1.26 (0.85–1.89) | 0.25 | 1.03 (0.71–1.51) | 0.87 |
| Ovary | |||||
| Not involved | 1006 | 1 | 1 | ||
| Involved | 34 | 1.84 (0.91–3.69) | 0.09 | 2.74 (1.35–5.56) | 0.005 |
| Peritoneal washing | 0.28 | 0.99 | |||
| No malignancy | 549 | 1 | 1 | ||
| Malignancy present | 55 | 1.58 (0.87–2.86) | 0.14 | 0.97 (0.50–1.91) | 0.93 |
| Not examined | 470 | 0.97 (0.66–1.42) | 0.87 | 0.87 (0.70–1.35) | 0.87 |
| Pelvic LNR (continuous) | 1,048 | 1.02 (1.01–1.03) | 0.001 | 1.03 (1.02–1.04) | <0.001 |
| Para-aortic lymph nodes | 0.28 | 0.09 | |||
| Not involved | 193 | 1 | 1 | ||
| Involved | 71 | 0.93 (0.58–1.48) | 0.75 | 2.15 (1.09–4.23) | 0.027 |
| Not examined | 810 | 0.53 (0.23–1.21) | 0.13 | 1.39 (0.88–2.20) | 0.16 |
An association of adjuvant treatment type and recurrence patterns was adjusted by a priori survival factors in Cox proportional-hazards regression models. The ratio of event number per the number of covariates was ≥10 indicating the absence of overfitting in the multivariate model. Abbreviations: HR, hazard ratio; CI, confidence interval; CCRT, concurrent chemoradiotherapy; RT, radiotherapy; SCC, squamous cell carcinoma; LVSI, lymphovascular invasion; LNR, lymph node ratio.