Table 5.

The association between preconception DAP concentrations and early IVF outcomes among 522 women (785 IVF cycles).

Outcomes	RR (95% CI)
	DMP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$)		DMTP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$)		DEP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$)		DETP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$)		${\mathrm{\Sigma }}_4\text{DAP}$ (nmol/g)
	Unadjusted	Adjusteda	Unadjusted	Adjusteda	Unadjusted	Adjusteda	Unadjusted	Adjusteda	Unadjusted	Adjusteda
Fertilization, proportion
Q1b	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
Q2b	1.08 (0.86, 1.36)	1.15 (0.91, 1.46)	1.07 (0.87, 1.32)	1.21 (0.92, 1.59)	1.11 (0.90, 1.38)	1.17 (0.94, 1.46)	0.92 (0.72, 1.18)	0.95 (0.74, 1.23)	0.89 (0.79, 1.23)	1.04 (0.84, 1.30)
Q3b	1.14 (0.91, 1.41)	1.12 (0.90, 1.41)	0.96 (0.76, 1.22)	0.89 (0.70, 1.12)	1.07 (0.85, 1.33)	1.12 (0.89, 1.42)	0.97 (0.79, 1.18)	0.98 (0.79, 1.21)	1.01 (0.81, 1.26)	1.04 (0.82, 1.31)
Q4b	1.05 (0.84, 1.32)	1.01 (0.80, 1.29)	0.98 (0.79, 1.20)	0.92 (0.75, 1.14)	1.08 (0.87, 1.34)	1.08 (0.86, 1.36)	1.04 (0.87, 1.24)	1.05 (0.86, 1.27)	1.03 (0.84, 1.27)	1.00 (0.81, 1.25)
$p$-trend	0.58	0.95	0.63	0.15	0.56	0.62	0.59	0.62	0.70	0.95
Total oocytes, count
Q1b	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
Q2b	0.89 (0.78, 1.03)	0.93 (0.82, 1.06)	1.00 (0.86, 1.17)	1.00 (0.87, 1.15)	0.91 (0.77, 1.07)	0.97 (0.83, 1.13)	0.91 (0.78, 1.06)	0.90 (0.78, 1.03)	0.82 (0.71, 1.15)	0.88 (0.76, 1.02)
Q3b	0.93 (0.81, 1.08)	0.96 (0.84, 1.10)	0.97 (0.82, 1.14)	1.01 (0.86, 1.18)	0.99 (0.84, 1.16)	1.00 (0.86, 1.16)	1.02 (0.87, 1.19)	1.04 (0.89, 1.21)	1.01 (0.88, 1.16)	1.05 (0.92, 1.19)
Q4b	0.92 (0.79, 1.08)	0.97 (0.83, 1.12)	0.97 (0.83, 1.14)	0.99 (0.85, 1.14)	0.98 (0.83, 1.16)	0.99 (0.85, 1.15)	0.96 (0.82, 1.13)	0.98 (0.85, 1.14)	0.95 (0.82, 1.09)	0.98 (0.85, 1.12)
$p$-trend	0.40	0.700	0.69	0.87	0.88	0.98	0.93	0.81	0.99	0.77
Total MII oocytes, count
Q1b	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
Q2b	1.02 (0.82, 1.27)	1.07 (0.88, 1.30)	0.97 (0.78, 1.21)	0.97 (0.79, 1.18)	0.93 (0.74, 1.18)	1.01 (0.83, 1.24)	0.92 (0.73, 1.15)	0.91 (0.74, 1.11)	0.81 (0.69, 1.15)	1.08 (0.87, 1.34)
Q3b	0.97 (0.75, 1.25)	1.00 (0.81, 1.25)	0.93 (0.70, 1.24)	0.99 (0.77, 1.26)	1.05 (0.83, 1.33)	1.14 (0.92, 1.41)	0.95 (0.74, 1.22)	1.04 (0.82, 1.32)	1.02 (0.88, 1.18)	1.08 (0.87, 1.34)
Q4b	0.97 (0.75, 1.26)	1.02 (0.81, 1.28)	0.98 (0.76, 1.26)	1.00 (0.80, 1.24)	1.07 (0.81, 1.41)	1.17 (0.93, 1.46)	1.03 (0.79, 1.33)	1.02 (0.82, 1.27)	0.94 (0.81, 1.09)	0.96 (0.78, 1.18)
$p$-trend	0.73	0.98	0.81	0.98	0.49	0.11	0.88	0.64	0.98	0.73
Best-quality embryos, count
Q1b	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
Q2b	0.97 (0.80, 1.18)	1.02 (0.85, 1.23)	1.01 (0.83, 1.23)	1.04 (0.87, 1.26)	1.01 (0.83, 1.24)	0.96 (0.78, 1.19)	0.91 (0.74, 1.11)	0.89 (0.73, 1.09)	0.87 (0.74, 1.02)	0.83 (0.67, 1.02)
Q3b	0.96 (0.78, 1.17)	0.99 (0.82, 1.19)	0.94 (0.76, 1.18)	1.00 (0.81, 1.22)	1.14 (0.92, 1.41)	1.12 (0.91, 1.40)	1.04 (0.82, 1.32)	1.07 (0.87, 1.31)	1.06 (0.92, 1.22)	1.02 (0.84, 1.24)
Q4b	1.02 (0.82, 1.27)	1.08 (0.88, 1.32)	0.96 (0.78, 1.18)	0.97 (0.80, 1.18)	1.17 (0.93, 1.46)	1.13 (0.92, 1.40)	1.02 (0.82, 1.27)	1.00 (0.80, 1.22)	0.97 (0.84, 1.13)	1.00 (0.81, 1.22)
$p$-trend	0.92	0.55	0.55	0.67	0.11	0.11	0.64	0.61	0.73	0.64
${\mathrm{E}}_2$ trigger levels, pmol/L
Q1b	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
Q2b	1.02 (0.94, 1.11)	1.04 (0.96, 1.13)	1.04 (0.96, 1.13)	1.04 (0.97, 1.12)	0.97 (0.88, 1.06)	0.99 (0.91, 1.08)	1.05 (0.96, 1.14)	1.05 (0.97, 1.13)	0.96 (0.88, 1.05)	1.01 (0.93, 1.10)
Q3b	1.00 (0.92, 1.08)	1.02 (0.95, 1.10)	1.01 (0.93, 1.10)	1.03 (0.95, 1.13)	1.01 (0.92, 1.10)	1.02 (0.94, 1.10)	1.09 (1.00, 1.19)	1.10 (1.01, 1.19)	1.03 (0.95, 1.12)	1.06 (0.98, 1.14)
Q4b	1.01 (0.93, 1.10)	1.03 (0.96, 1.12)	1.04 (0.96, 1.12)	1.04 (0.96, 1.12)	1.01 (0.93, 1.10)	1.02 (0.94, 1.10)	1.03 (0.95, 1.12)	1.04 (0.96, 1.12)	1.02 (0.94, 1.10)	1.04 (0.96, 1.12)
$p$-trend	0.97	0.51	0.53	0.39	0.51	0.56	0.29	0.17	0.38	0.21
Endometrial wall thickness (mm)
Q1b	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
Q2b	0.97 (0.55, 1.71)	0.99 (0.59, 1.71)	1.00 (0.57, 1.75)	1.18 (0.69, 1.84)	1.36 (0.77, 2.38)	1.49 (0.89, 2.52)	1.09 (0.63, 1.90)	0.99 (0.58, 1.69)	0.50 (0.29, 0.88)	0.60 (0.35, 1.03)
Q3b	0.85 (0.49, 1.49)	0.90 (0.53, 1.53)	0.78 (0.46, 1.32)	0.82 (0.50, 1.36)	1.16 (0.66, 2.04)	1.16 (0.68, 1.97)	0.78 (0.45, 1.35)	0.77 (0.45, 1.30)	0.89 (0.51, 1.55)	0.92 (0.54, 1.58)
Q4b	0.61 (0.34, 1.08)	0.65 (0.38, 1.13)	0.99 (0.56, 1.78)	1.04 (0.62, 1.78)	1.23 (0.69, 2.20)	1.27 (0.74, 2.19)	0.80 (0.44, 1.44)	0.82 (0.47, 1.41)	0.60 (0.35, 1.05)	0.67 (0.40, 1.15)
$p$-trend	0.09	0.13	0.79	0.85	0.64	0.62	0.29	0.33	0.25	0.35

Note: Associations between preconception DAP concentrations and early IVF outcomes were estimated using GEE models. BMI, body mass index; CI, confidence interval; DAP, dialkylphosphate; DEP, diethylphosphate; DETP; diethylthiophosphate; DMP, dimethylphosphate; DMTP, dimethylthiophosphate; GEE, generalized estimating equations; IVF, in vitro fertilization; PSS, Perceived Stress Scale; RR, risk ratios; PSS, Perceived Stress Scale; RR, risk ratio.

^aAdjusted for age, BMI, duration of infertility, smoking status, education, annual household income, infertility diagnosis, two items from the PSS-10 questionnaire (“Have you been upset because of something that happened unexpectedly?” and “Have felt unable to control the important things in your life?”).

^bThe cut points of DAP metabolites were the same as the cut points shown in Table 4.