Table 6.

Adjusted RR (95% CI) for DAP concentrations and clinical outcomes stratified by age among 522 women (785 IVF cycles).

Exposure	Adjusted RR (95% CI)a
	Implantation				Clinical pregnancy				Live birth
	$<35\text{\hspace{0.17em}years}$ (196 women, 236 cycles)		$\ge 35\text{\hspace{0.17em}years}$ (77 women, 108 cycles)		$<35\text{\hspace{0.17em}years}$ (173 women, 207 cycles)		$\ge 35\text{\hspace{0.17em}years}$ (64 women, 86 cycles)		$<35\text{\hspace{0.17em}years}$ (167 women, 201 cycles)		$\ge 35\text{\hspace{0.17em}years}$ (61 women, 81 cycles)
DMP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$)
Q1b	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value
Q2b	1.32 (0.89, 1.95)	0.16	0.88 (0.69, 1.12)	0.30	1.13 (0.82, 1.56)	0.46	0.91 (0.74, 1.11)	0.34	1.10 (0.80, 1.51)	0.55	0.90 (0.73, 1.10)	0.29
Q3b	1.20 (0.79, 1.81)	0.39	0.88 (0.69, 1.12)	0.30	1.10 (0.79, 1.53)	0.58	0.94 (0.76, 1.15)	0.53	1.09 (0.79, 1.51)	0.61	0.96 (0.79, 1.17)	0.67
Q4b	0.93 (0.59, 1.47)	0.76	0.80 (0.60, 1.05)	0.11	0.95 (0.65, 1.38)	0.77	0.89 (0.70, 1.11)	0.30	0.96 (0.67, 1.40)	0.83	0.94 (0.76, 1.16)	0.56
$p$-trend	0.75	—	0.13	—	0.81	—	0.37	—	0.88	—	0.71	—
$p$-interaction	0.56		—		0.79		—		0.90		—
DMTP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$)
Q1b	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value
Q2b	0.86 (0.58, 1.27)	0.43	0.75 (0.59, 0.95)	0.02	0.85 (0.60, 1.19)	0.34	0.80 (0.65, 0.99)	0.04	0.87 (0.62, 1.22)	0.41	0.88 (0.72, 1.07)	0.20
Q3b	1.16 (0.79, 1.69)	0.45	0.80 (0.63, 1.01)	0.06	1.23 (0.90, 1.69)	0.19	0.93 (0.76, 1.13)	0.47	1.19 (0.88, 1.63)	0.26	0.93 (0.77, 1.13)	0.47
Q4b	0.87 (0.58, 1.30)	0.51	0.91 (0.71, 1.15)	0.41	0.96 (0.70, 1.33)	0.81	0.98 (0.80, 1.20)	0.82	0.98 (0.72, 1.35)	0.91	0.99 (0.82, 1.20)	0.91
$p$-trend	0.85	—	0.56	—	0.66	—	0.91	—	0.57	—	0.98	—
$p$-interaction	0.12		—		0.41		—		0.45		—
DEP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$)
Q1b	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value
Q2b	0.93 (0.64, 1.35)	0.71	0.90 (0.72, 1.12)	0.35	0.92 (0.67, 1.25)	0.60	0.91 (0.76, 1.09)	0.29	0.95 (0.70, 1.29)	0.73	0.93 (0.79, 1.11)	0.44
Q3b	0.83 (0.56, 1.22)	0.35	0.75 (0.59, 0.97)	0.03	0.81 (0.58, 1.12)	0.20	0.76 (.62, 0.93)	0.01	0.85 (0.61, 1.17)	0.32	0.77 (0.64, 0.94)	0.01
Q4b	0.76 (0.49, 1.17)	0.21	0.68 (0.53, 0.88)	0.003	0.88 (0.62, 1.24)	0.45	0.72 (0.59, 0.89)	0.002	0.91 (0.65, 1.28)	0.58	0.76 (0.62, 0.92)	0.01
$p$-trend	0.19	—	0.001	—	0.33	—	0.001	—	0.45	—	0.002	—
$p$-interaction	0.82		—		0.44		—		0.48		—
DETP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$)
Q1b	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value
Q2b	1.47 (1.02, 2.12)	0.05	0.77 (0.61, 0.98)	0.04	1.30 (0.95, 1.77)	0.11	0.90 (0.74, 1.09)	0.29	1.36 (1.00, 1.84)	0.05	0.89 (0.74, 1.08)	0.24
Q3b	0.86 (0.55, 1.34)	0.50	0.74 (0.57, 0.96)	0.02	0.92 (0.63, 1.33)	0.65	0.82 (0.66, 1.02)	0.08	0.88 (0.61, 1.27)	0.59	0.81 (0.66, 1.01)	0.05
Q4b	0.95 (0.62, 1.47)	0.82	0.83 (0.66, 1.05)	0.12	1.05 (0.75, 1.49)	0.76	0.87 (0.70, 1.07)	0.18	1.07 (0.76, 1.50)	0.70	0.86 (0.70, 1.04)	0.13
$p$-trend	0.29	—	0.12	—	0.75	—	0.14	—	0.72	—	0.09	—
$p$-interaction	0.32		—		0.40		—		0.35		—
${\mathrm{\Sigma }}_4\text{DAP}$ (nmol/g)
Q1b	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value
Q2b	1.12 (0.78, 1.60)	0.54	0.98 (0.77, 1.25)	0.90	0.94 (0.70, 1.26)	0.68	0.98 (0.80, 1.20)	0.83	0.98 (0.73, 1.32)	0.90	0.98 (0.81, 120)	0.86
Q3b	0.76 (0.49, 1.17)	0.21	0.88 (0.68, 1.14)	0.33	0.81 (0.58, 1.14)	0.23	0.89 (0.72, 1.10)	0.27	0.85 (0.60, 1.19)	0.34	0.91 (0.75, 1.11)	0.35
Q4b	0.89 (0.58, 1.38)	0.61	0.69 (0.51, 0.93)	0.02	0.86 (0.60, 1.23)	0.42	0.76 (0.60, 0.97)	0.03	0.91 (0.64, 1.29)	0.60	0.81 (0.64, 1.01)	0.06
$p$-trend	0.25	—	0.002	—	0.26	—	0.003	—	0.43	—	0.01	—
$p$-interaction	0.68		—		0.78		—		0.82		—

Note: —, no data; BMI, body mass index; DAP, dialkylphosphate; DEP, diethylphosphate; DETP, diethylthiophosphate; DMP, dimethylphosphate; DMTP, dimethylthiophosphate; GEE, generalized estimating equations; IVF, in vitro fertilization; PSS, Perceived Stress Scale; RR, risk ratios.

^aAdjusted for BMI, duration of infertility, smoking status, education, annual household income, infertility diagnosis, two items from the PSS-10 questionnaire (“Have you been upset because of something that happened unexpectedly?” and “Have felt unable to control the important things in your life?”).

^bThe cut point of DAP metabolites for younger women ($<35\mathrm{y}$): DMP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 0.30$), Q2 (0.31–4.94), Q3 (4.95–18.84), Q4 ($\ge 18.85$); DMTP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 0.73$), Q2 (0.74–1.44), Q3 (1.45–2.47), Q4 ($\ge 2.48$); DEP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 1.50$), Q2 (1.51–11.72), Q3 (11.73–45.41), Q4 ($\ge 45.42$); DETP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 0.99$), Q2 (1.00–1.85), Q3 (1.86–3.56), Q4 ($\ge 3.57$); ${\mathrm{\Sigma }}_4\text{DAP}$ (nmol/g): Q1 ($\le 45.35$), Q2 (45.36–242.20), Q3 (242.21–655.12), Q4 ($\ge 655.13$).

The cut point for older women ($\ge 35\mathrm{y}$): DMP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 0.77$), Q2 (0.78–9.05), Q3 (9.06–27.38), Q4 ($\ge 27.39$); DMTP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 0.81$), Q2 (0.82–1.40), Q3 (1.41–2.62), Q4 ($\ge 2.63$); DEP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 0.69$), Q2 (0.70–8.68), Q3 (8.69–36.29), Q4 ($\ge 36.30$); DETP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 1.04$), Q2 (1.05–1.85), Q3 (1.86–3.25), Q4 ($\ge 3.26$); ${\mathrm{\Sigma }}_4\text{DAP}$ (nmol/g): Q1 ($\le 74.29$), Q2 (74.30–236.13), Q3 (236.14–538.34), Q4 ($\ge 538.35$).