Table 7.

Adjusted RR (95% CI) for DAP concentrations and clinical outcomes stratified by BMI among 522 women (785 IVF cycles).

Exposure	Adjusted RR (95% CI)a
	Implantation				Clinical pregnancy				Live birth
	$<24{\mathrm{kg}/\mathrm{m}}^2$ (218 women, 272 cycles)		$\ge 24{\mathrm{kg}/\mathrm{m}}^2$ (55 women, 72 cycles)		$<24{\mathrm{kg}/\mathrm{m}}^2$ (190 women, 232 cycles)		$\ge 24{\mathrm{kg}/\mathrm{m}}^2$ (47 women, 61 cycles)		$<24{\mathrm{kg}/\mathrm{m}}^2$ (182 women, 222 cycles)		$\ge 24{\mathrm{kg}/\mathrm{m}}^2$ (46 women, 60 cycles)
DMP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$)
Q1b	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value
Q2b	1.08 (0.84, 1.38)	0.55	0.80 (0.55, 1.15)	0.22	1.05 (0.85, 1.29)	0.67	0.89 (0.63, 1.25)	0.49	1.04 (0.84, 1.27)	0.74	0.93 (0.67, 1.29)	0.66
Q3b	0.92 (0.70, 1.21)	0.53	0.90 (0.64, 1.26)	0.54	0.91 (0.72, 1.14)	0.42	1.01 (0.73, 1.40)	0.95	0.90 (0.72, 1.13)	0.37	1.02 (0.74, 1.40)	0.90
Q4b	1.01 (0.76, 1.33)	0.95	0.57 (0.38, 0.83)	0.004	1.06 (0.84, 1.33)	0.64	0.67 (0.46, 0.99)	0.05	1.11 (0.89, 1.39)	0.35	0.69 (0.47, 1.00)	0.06
$p$-trend	0.78	—	0.01	—	0.94	—	0.07	—	0.60	—	0.07	—
$p$-interaction	0.14		—		0.27		—		0.19		—
DMTP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$)
Q1b	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value
Q2b	0.84 (0.64, 1.08)	0.17	1.16 (0.83, 1.64)	0.39	0.86 (0.68, 1.09)	0.22	1.05 (0.75, 1.46)	0.78	0.91 (0.73, 1.15)	0.44	1.08 (0.78, 1.50)	0.63
Q3b	0.95 (0.73, 1.22)	0.66	0.86 (0.61, 1.21)	0.39	1.04 (0.84, 1.29)	0.73	1.04 (0.78, 1.39)	0.77	1.03 (0.83, 1.27)	0.80	1.05 (0.79, 1.40)	0.72
Q4b	0.81 (0.62, 1.05)	0.11	1.00 (0.68, 1.48)	0.99	0.91 (0.73, 1.14)	0.42	0.95 (0.67, 1.35)	0.77	0.95 (0.77, 1.18)	0.65	0.95 (0.68, 1.34)	0.77
$p$-trend	0.22	—	0.60	—	0.78	—	0.81	—	0.90	—	0.79	—
$p$-interaction	0.76		—		0.97		—		0.97		—
DEP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$)
Q1b	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value
Q2b	0.88 (0.70, 1.12)	0.32	0.99 (0.77, 1.33)	0.94	0.90 (0.74, 1.09)	0.28	0.96 (0.75, 1.25)	0.78	0.94 (0.77, 1.14)	0.51	0.97 (0.76, 1.25)	0.83
Q3b	0.74 (0.57, 0.94)	0.02	0.95 (0.68, 1.33)	0.78	0.75 (0.61, 0.94)	0.01	0.81 (0.60, 1.11)	0.19	0.78 (0.63, 0.96)	0.02	0.85 (0.63, 1.14)	0.27
Q4b	0.70 (0.53, 0.93)	0.01	0.77 (0.61, 1.00)	0.05	0.77 (0.61, 0.98)	0.03	0.77 (0.60, 1.01)	0.05	0.82 (0.66, 1.04)	0.09	0.77 (0.60, 1.06)	0.06
$p$-trend	0.004	—	0.08	—	0.01	—	0.05	—	0.05	—	0.08	—
$p$-interaction	0.09		—		0.32		—		0.34		—
DETP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$)
Q1b	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value
Q2b	1.10 (0.86, 1.41)	0.44	1.11 (0.77, 1.61)	0.57	1.13 (0.92, 1.39)	0.25	1.13 (0.79, 1.61)	0.52	1.15 (0.93, 1.41)	0.20	1.17 (0.83, 1.66)	0.38
Q3b	0.90 (0.68, 1.18)	0.45	0.82 (0.57, 1.18)	0.29	0.92 (0.73, 1.17)	0.51	0.77 (0.52, 1.14)	0.19	0.92 (0.73, 1.15)	0.46	0.78 (0.52, 1.15)	0.20
Q4b	0.86 (0.66, 1.12)	0.25	0.90 (0.63, 1.28)	0.56	0.91 (0.72, 1.14)	0.39	1.01 (0.72, 1.41)	0.96	0.92 (0.74, 1.15)	0.45	1.02 (0.73, 1.43)	0.89
$p$-trend	0.13	—	0.31	—	0.18	—	0.59	—	0.19	—	0.60	—
$p$-interaction	0.98		—		0.52		—		0.34		—
${\mathrm{\Sigma }}_4\text{DAP}$ (nmol/g)
Q1b	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value	Ref	$p$-value
Q2b	0.98 (0.78, 1.24)	0.88	1.15 (0.85, 1.56)	0.35	0.90 (0.73, 1.10)	0.29	1.05 (0.78, 1.41)	0.75	0.89 (0.73, 1.09)	0.26	1.09 (0.83, 1.45)	0.53
Q3b	0.71 (0.54, 0.93)	0.01	0.94 (0.70, 1.26)	0.69	0.73 (0.58, 0.92)	0.008	0.90 (0.70, 1.17)	0.43	0.77 (0.61, 0.96)	0.02	0.91 (0.70, 1.17)	0.44
Q4b	0.83 (0.63, 1.11)	0.21	0.70 (0.45, 1.07)	0.10	0.86 (0.68, 1.09)	0.22	0.71 (0.49, 1.04)	0.08	0.91 (0.73, 1.14)	0.41	0.71 (0.50, 1.03)	0.07
$p$-trend	0.06	—	0.06	—	0.09	—	0.05	—	0.25	—	0.06	—
$p$-interaction	0.80		—		0.45		—		0.58		—

Note: —, no data; BMI, body mass index; DAP, dialkylphosphate; DEP, diethylphosphate; DETP, diethylthiophosphate; DMP, dimethylphosphate; DMTP, dimethylthiophosphate; GEE, generalized estimating equations; IVF, in vitro fertilization; PSS, Perceived Stress Scale; RR, risk ratios.

^aAdjusted for age, duration of infertility, smoking status, education, annual household income, infertility diagnosis, two items from the PSS-10 questionnaire (“Have you been upset because of something that happened unexpectedly?” and “Have felt unable to control the important things in your life?”).

^bThe cut point of DAP metabolites for lean women ($<24{\mathrm{kg}/\mathrm{m}}^2$): DMP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 0.33$), Q2 (0.34–7.03), Q3 (7.04–27.13), Q4 ($\ge 27.14$); DMTP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 0.81$), Q2 (0.82–1.51), Q3 (1.52–2.65), Q4 ($\ge 2.66$); DEP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 1.01$), Q2 (1.02–9.05), Q3 (9.06– 42.90), Q4 ($\ge 42.91$); DETP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 1.04$), Q2 (1.05–1.88), Q3 (1.89–3.56), Q4 ($\ge 3.57$); ${\mathrm{\Sigma }}_4\text{DAP}$ (nmol/g): Q1 ($\le 52.23$), Q2 (52.24–243.84), Q3 (243.85–669.93), Q4 ($\ge 669.94$).

The cut point for overweight/obese women ($\ge 24{\mathrm{kg}/\mathrm{m}}^2$): DMP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 0.96$), Q2 (0.97–6.35), Q3 (6.36–14.19), Q4 ($\ge 14.20$); DMTP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 0.69$), Q2 (0.70–1.19), Q3 (1.20–2.20), Q4 ($\ge 2.21$); DEP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 0.69$), Q2 (0.70–1.19), Q3 (1.20–36.68), Q4 ($\ge 36.69$); DETP ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$): Q1 ($\le 1.00$), Q2 (1.01–1.84), Q3 (1.85–3.32), Q4 ($\ge 3.33$); ${\mathrm{\Sigma }}_4\text{DAP}$ (nmol/g): Q1 ($\le 73.00$), Q2 (73.01–219.15), Q3 (219.16–423.96), Q4 ($\ge 423.97$).