Table 1.

Cohort demographics from UPENN CNDR and UK-ADC

	UPENN CNDR		UK-ADC
	FTLD-TDP	LATE-NC	FTLD-TDP	LATE-NC
n	33	30	8	14
Age at death (mean ± SD)	66.6 ± 9.3	88.6 ± 6.4	62.9 ± 9.8	90.9 ± 8.5
Clinical diagnosis at last exama
No documented impairment	0	0	2	0
Mild cognitive impairment	0	3	0	0
Vascular dementia	0	1	0	2
Probable Alzheimer’s disease	2	26	0	12
bvFTD-FTLD	2	0	2	0
bvFTD-FTLD/MND	5	0	2	0
bvFTD-FTLD/PPA	5	0	2	0
Genetics
C9orf72 expansion	11	0	N/A	N/A
GRN variant	7	0	N/A	N/A
TBK1 variant	1	0	N/A	N/A
VCP mutation	0	0	1	N/A
FTLD-TDP type
Type A or B	23	N/A	4	N/A
Type C	6	N/A	2	N/A
Type D	0	N/A	1	N/A
Type E	4	N/A	1	N/A
LATE-NC stage
Stage 0	N/A	0	N/A	0
Stage 1	N/A	0	N/A	0
Stage 2	N/A	2	N/A	9
Stage 3	N/A	28	N/A	5
Intermediate/high ADNCb	4	28	0	0

bvFTD = behavioural variant FTD; MND = motor neuron disease; N/A = not assessed; PPA = primary progressive aphasia.

^aFor clinical diagnostic criteria and definitions, see ‘Materials and methods’ section.

^bAccording to NIA-AA neuropathological criteria (Hyman and Trojanowski, 1997).