Table 3.

FTLD-TDP type A/B versus LATE-NC pathological severity differences

TDP-43 pathological feature	FTLD-TDP type A/B cases only versus LATE-NC comparison by pathological feature: P-values
	Amygdala	Anterior cingulate	Superior temporal	Middle frontal
Ropy DN	0.17	<0.001	<0.001	<0.001
NCI	0.57	<0.001	<0.001	<0.001
WM GCI	0.001	<0.001	<0.001	<0.001
Punctate DN	0.03	<0.001	0.003	<0.001
NII	0.05	<0.001	<0.001	<0.001
Compact PV	0.16	0.17	0.45	0.04

P-values for Mann-Whitney-Wilcoxon tests for comparison of the LATE-NC cases (n = 30) and the FTLD-TDP Type A/B cases (n = 24), i.e. FTLD-TDP types C–E cases were excluded in this analysis. Shown are results from UPENN cases as read blind by UK-ADC neuropathologists. Compact PV = compact perivascular lesions as described by Lin et al. (2009). DN = various types of TDP-43 immunoreactive dystrophic neurites; NCI = neuronal cytoplasmic inclusion; NII = neuronal intranuclear inclusion; WM GCI = white matter glial cytoplasmic inclusion.