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. 2020 Jun 7;105(12):e4275–e4289. doi: 10.1210/clinem/dgaa357

Figure 4.

Figure 4.

Effects of H 2 S donors on pregnancy in CBS-deficiency mice and a spontaneous abortion mouse model. (A) Litter size in WT x ♂CBS+/– and WT x WT dams. Embryonic resorption and representative uteri with fetuses on gestational day 12.5 in CBS+/– cross-breading (♀WT/♂CBS+/– and ♂ WT/♀CBS+/–) and wild-type (WT) dams (B). The H2S donor (GYY or NaHS)-treated CBS+/– dams (C, WT as control) and CBA/J x DBA/2 spontaneous abortion dams (D, C57BL/6 x DBA/2 dams as control). Black arrowheads denote the resorption sites. The numbers within bars indicate the number of dams examined; the numbers above bars indicate the number of resorption events divided by the number of implantation sites. Differences between groups were indicated. CBS, cystathionine β-synthase; GYY, GYY4137; H2S, hydrogen sulfide; NaHS, sodium hydrosulfide; WT, wild-type.