Figure 6.
Dysregulated H 2 S signaling on Th1 and Th2 cytokine production in the decidua of resorbed fetuses. Decidua tissues were isolated from gestational day (GD)12.5 dams with resorbed fetuses; the tissue samples were homogenized for determining IL-4, IL-6, TNF-ɑ, IFN-γ, and TGF-β levels by ELISA. (A) Wild-type (WT) dams receiving AOAA (50 mg/kg) or PAG (100 mg/kg) or PBS (indicated as control, pH = 7.2) as indicated in Figure 5. (B) CBS+/– cross-breading (♀WT/♂CBS+/– and ♂ WT/♀CBS+/–) and WT dams. Data were presented as means ± SD. * P < 0.05. AOAA, amino-oxyacetic acid; CBS, cystathionine β-synthase; ELISA, enzyme-linked immunosorbent assay; H2S, hydrogen sulfide; IL, interleukin; n.s., not significant; PAG, propargylglycine; PBS, phosphate buffered saline; SD, standard deviation; TGF, tumor growth factor; Th, T-helper; TNF, tumor necrosis factor.