Table 4.
Antihyperglycemic Effect of Root Crude Extract Acanthus polystachyus Against Streptozocin–Nicotinamide-Induced Diabetic Rats
| Group | Blood Glucose Level (mg/dl) at Weekly Interval | ||||
|---|---|---|---|---|---|
| Day 0 | Day 7 | Day 14 | Day 21 | Day 28 | |
| DW10ml/kg | 294.83±7.41 | 290.17±4.21 | 289.33±5.43 | 288.17±3.66 | 288.33±5.13 |
| APRE100mg/kg | 293.67±7.76 | 274.50±4.97a***b***cd*e*** | 274.33±4.63a**b***d*e*** | 271.83±3.25a***b***d*e*** | 271.16±3.06a***b***d*e*** |
| APRE200mg/kg | 294.17±6.21 | 271.67±4.67a***b***c*e*** | 268.83±3.31a***b***c*e*** | 267.00±5.06a***b***c*e*** | 264.83±5.19a***b***c*e*** |
| APRE400mg/kg | 295.33±8.82 | 240.83±7.08a***b***c***d*** | 236.83±6.79a***b***c***d*** | 234.83±7.47a***b***c***d*** | 234.50±7.66a***b***c***d*** |
| GLC5mg/kg | 295.67±8.36 | 173.16±5.91a***c***d***e*** | 169.66±6.74a***c***d***e*** | 167.33±5.72a***c***d***e*** | 166.17± 4.87a***c***d***e*** |
Notes: Data are expressed as mean ± SEM; No. of animals (N) = 6; a, compared to negative control; b compared to positive control, c to 100mg/kg, d to 200 mg/kg, e to 400 mg/kg; *p>0.05 (not significant), **p<0.01, ***p<0.001.