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. 2017 Feb 1;113(6):633–643. doi: 10.1093/cvr/cvx016

Figure 5.

Figure 5

OPN aptamer reverses cardiac dysfunction in TAC wild type mice. Echocardiographic time series at baseline or 1 month-, 2 month (before injections)-, and 2.5 month (after injections)-post-TAC show significant improvement in cardiac function of OPN aptamer-injected mice. Detailed echocardiographic data and statistics are shown in Supplementary material online, Table SIV. N = 3-6 mice per group. Error bars = SEM. P-values are from Repeated Measures ANOVA with Tukey post hoc correction when following the same mice over time. **P ≤0.01. WT, wild type; TAC, Transverse Aortic Constriction; OPN-Apt, OPN aptamer; Mut-Apt, Mutant aptamer; EF, Ejection Fraction; LVPWd, Left Ventricular Posterior Wall, diastole.