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Schematic overview of the mechanisms involved in the systemic endothelial dysfunction that is present in patients with rheumatic inflammatory diseases, in relation to the occurrence of cardiovascular events. IFN, interferon; IL-2, interleukin-2; PA, psoriatic arthritis; RA, rheumatic arthritis; RFs, risk factors; SLE, systemic lupus erythematosus; SS, systemic sclerosis; TNF, tumour necrosis factor.
