Figure 2.

GTF2I binds at promoters in conserved, active sites in the genome. (A) GTF2I binding sites are annotated mostly in gene promoters and the gene body. The distribution of peaks is significantly different than would be expected by chance. (B) GTF2I peaks overlap with H3K4me3 peaks marking active regions, and to a lesser extent GTF2I peaks fall within H3K27me3 peaks marking inactive regions. (C) GO analysis of genes that have GTF2I bound at the promoter. (D) Epigenome browser shot of GTF2I peak bound within the Src gene. (E) Genomic sequence under GTF2I peaks is more conserved than random regions of the genome and a random set of promoter regions. (F) Motifs of transcription factors that are enriched in GTF2I-bound sequences. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.