FIG 2.

Action of occidiofungin on Cryptosporidium parvum sporozoites and oral stability of occidiofungin in mice. (A) Deformation of the morphology of sporozoites after treatment with occidiofungin at 400 nM for 40 min. All treatment groups contained 0.5% DMSO, including controls. DIC, differential interference contrast microscopy; TRITC, tetramethylrhodamine isothiocyanate (sporozoites were labeled by a rabbit polyclonal antibody against C. parvum total proteins and TRITC-conjugated secondary antibody). (B) Concentrations of occidiofungin in BALB/c mouse feces 10 h after a single oral daily dose (50 mg/kg) for 3 days. (C) Mouse weight gain or loss 10 h after the third dose of occidiofungin (versus fluconazole at 50 mg/kg/day).