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Bacterial burdens in mouse lungs after 1 day of treatment with tebipenem-PI and comparators (comparator antibiotics polymyxin B and tigecycline were administered intravenously, while meropenem was dosed via subcutaneous [s.c.] injection). (A and B) K. pneumoniae ATCC 43816 after 24 h of treatment with either tebipenem-PI dosed q24h (A) or tebipenem-PI dosed q8h p.o. (B); (C) P. aeruginosa ATCC 27853 after 14 h of treatment with tebipenem-PI dosed q8h p.o.
