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Bacterial burdens in mouse urinary tract infections after treatment with tebipenem-PI or comparators (levofloxacin or ciprofloxacin). Shown are burdens of E. coli ATCC 700928 in kidney (A) bladder (B), and urine (C) and E. coli UTI89 in kidney (D). Paired t tests of treated versus untreated group results on day 4 are shown as follows: ns, not significant; *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; and ****, P ≤ 0.0001.
