TABLE 2.

MICs of tebipenem and comparators against anaerobic clinical isolates

Organism(s)	n	MIC50/90 (μg/ml)a
		Tebipenem	Meropenem	Metronidazole
Bacteroides sp.	25	0.5/2	1/4	1/1
Fusobacterium spp.	10	≤0.015	≤0.015/0.06	≤0.06/0.25
Porphyromonas spp.	10	0.03/0.06	0.06	0.25/1
Prevotella spp.	30	0.125/0.25	0.25	0.5/2
Clostridioides difficile	10	2	2/4	0.25/0.5
Gram-positive rodsc	12	0.03/0.25	≤0.03/0.25	16/>16
Gram-positive spore-forming rodsd	48	0.5/2	0.25/2b	0.5/2
Gram-positive non-spore-forming rodse	26	0.06/1	0.25/8	2/>16
Gram-positive coccif	24	0.06/0.25	0.125/0.25	0.25/1

^aAgar dilution method according to procedures described in CLSI document M11-A8 (27).

^bn = 38.

^cGram-positive rods: Actinomyces europaeus, Actinomyces israelii, Actinomyces neuii subsp. neuii, Actinomyces odontolyticus, Actinomyces turicensis, Anaerostipes caccae, Bifidobacterium adolescentis, Bifidobacterium catenulatum, and Bifidobacterium pseudocatenulatum.

^dGram-positive spore-forming rods: Clostridioides aldenense, Clostridium bolteae, Clostridium butyricum, Clostridium celerecrescens, Clostridium citroniae, C. clostridioforme, Hungatella hathewayi, Clostridium novyi A, C. perfringens, Clostridium ramosum, C. difficile, Clostridium scindens, Clostridium sporogenes, Clostridium symbiosum, and Robinsoniella peoriensis.

^eGram-positive non-spore-forming rods: Collinsella aerofaciens, Collinsella sp., Eggerthella lenta, Eubacterium limosum, Catabacter hongkongensis, Faecalitalea cylindroides, Lactobacillus casei, Lactobacillus fermentum, L. rhamnosus GG, L. rhamnosus, and Lactobacillus salivarius.

^fAnaerobic Gram-positive cocci: Finegoldia magna, Parvimonas micra, Parvimonas sp., Peptostreptococcus anaerobius, Ruminococcus gnavus, R. gnavus-like, Ruminococcus torques, Ruminococcus productus, and Blautia sp.