TABLE 3.
Impact of inoculum on MICs of tebipenem and meropenema
| Organism | ESBLb | Compound | MIC under standard conditions | Impact of FINAL Inoculum (CFU/ml) (fold change) |
||
|---|---|---|---|---|---|---|
| 5.0 × 104 | 5.0 × 106 | 5.0 × 107 | ||||
| E. coli ATCC 25922 | N | Tebipenem | 0.015 | 0.015 (0) | 0.06 (4) | >32 |
| Meropenem | 0.015 | 0.03 (2) | 0.06 (4) | >32 | ||
| E. coli ATCC 35218 | Y | Tebipenem | 0.015 | 0.015 (0) | 0.03 (2) | >32 |
| Meropenem | 0.015 | 0.015 (0) | 0.03 (2) | >32 | ||
| K. pneumoniae ATCC 43816 | N | Tebipenem | 0.03 | 0.03 (0) | 0.12 (4) | >32 |
| Meropenem | 0.03 | 0.03 (0) | 0.06 (2) | >32 | ||
| K. pneumoniae ATCC 700603 | Y | Tebipenem | 0.06 | 0.06 (0) | 0.25 (4) | >32 |
| Meropenem | 0.03 | 0.03 (0) | 0.25 (8) | >32 | ||
| P. mirabilis ATCC 43071 | N | Tebipenem | 0.12 | 0.03 (−4) | 8 (64) | >32 |
| Meropenem | 0.06 | 0.03 (−2) | 2 (32) | >32 | ||
| P. mirabilis MMX 6343 | Y | Tebipenem | 0.5 | 0.12 (−8) | 8 (16) | >32 |
| Meropenem | 0.12 | 0.03 (−8) | 1 (8) | >32 | ||
a
MICs are in micrograms per milliliter. Bold indicates >4× differences from CLSI standard inoculum (∼5 × 105 CFU/ml).
b
N, no; Y, yes.