TABLE 4.

Effect of varying the pH on antibacterial activity of tebipenem in media and pooled human urine

Testing condition	Compound	Tebipenem MIC (μg/ml)
		E. coli ATCC 25922, non-ESBL	E. coli ATCC 35218, ESBL	K. pneumoniae ATCC 43816, non-ESBL	K. pneumoniae ATCC 700603, ESBL	P. mirabilis ATCC 43071, non-ESBL	P. mirabilis MMX 6343, ESBL
pH 5	Tebipenem	0.06	0.03	0.03	0.06	1	1
	Meropenem	0.12	0.06	0.06	0.06	0.5	1
pH 6	Tebipenem	0.03	0.015	0.03	0.06	1	1
	Meropenem	0.06	0.03	0.06	0.06	0.5	1
pH 7	Tebipenem	0.015	0.015	0.03	0.12	0.12	0.5
	Meropenem	0.015–0.03	0.015–0.03	0.03–0.06	0.03–0.06	0.06	0.12–0.25
pH 8	Tebipenem	0.03	0.015	0.03	0.12	0.12	0.5
	Meropenem	0.06	0.06	0.12	0.06	0.06	0.12
Human urinea	Tebipenem	0.015	0.015	0.03	0.06	0.5	2
	Meropenem	0.03	0.015	0.03	0.06	0.25	0.5

^aPooled human urine at pH 6.9.