TABLE 3.
Physicochemical properties in vitro and population pharmacokinetic data for tenofovir alafenamide
| Propertya | Value for tenofovir alafenamide (reference) |
|---|---|
| Mol wt | 476.474 (44) |
| Solubility in water | 4.86 mg/ml (44) |
| Log Po:w | 1.6 (44) |
| pKa | 3.96 (44) |
| Blood-to-plasma ratio | 1.5b |
| Protein binding | 80 % (44) |
| Absorption rate | 6.24 h−1 (38) |
| Apparent clearance | 149 liters/h (38) |
| Oral bioavailability | 0.53c (38) |
a
Log Po:w, partition coefficient between octanol and water; pKa, logarithmic value of the dissociation constant.
b
Mean of 0.6 and 2.4.
c
Assumed since 47.2% ± 4.62% is excreted in feces.