FIG 1.

Observed meropenem and vaborbactam murine concentration-time profile compared with human simulation PK1. Observed concentrations of free meropenem and vaborbactam in the neutropenic murine thigh infection model after meropenem-vaborbactam 300/50 mg/kg administered intraperitoneally q2h. Plasma sampling occurred at 0.75, 1, 2.25, 3, 5, 5.5, and 7.75 h. Solid lines, human simulations derived from healthy volunteers for meropenem and vaborbactam. Dashed lines, estimated simulated murine exposure based on indices reported by Sabet et al. (14) from uninfected mice. Circles (red) and triangles (green), observed murine meropenem and vaborbactam concentrations (means ± SD), respectively.