FIG 3.

MIC distributions of various beta-lactam–BLI combinations against KPC-producing strains of K. pneumoniae with defective (DEF) (n = 135) or functional (FL) (n = 95) OmpK36. OmpK36 was considered defective if frameshift and nonsense mutations, large insertions, a duplication of two amino acids (Gly134 and Asp135 [GD repeat], located within the L3 internal loop, resulting in the constriction of the channel), or reduced expression due to insertions in the promoter region has been identified. Otherwise, it was assumed to be functional.