TABLE 3.

In vitro potencies of meropenem alone and combined with QPX7728 at various concentrations against carbapenem-resistant strains of Enterobacterales according to carbapenemase

CRE (no. of strains)	Agent(s)	No. of strains inhibited at meropenem MIC (μg/ml) of:a
		≤0.06	0.125	0.25	0.5	1	2	4	8	16	32	64	>64
KPC (285)	MER	1	0	0	2	3	3	14	30	45	28	29	130
	MER + QPX at 4 μg/ml	165	43	30	17	9	7	5	2	1	2	2	2
	MER + QPX at 8 μg/ml	203	32	31	11	4	2	2	0	0	0	0	0
K. pneumoniae KPC (230)	MER	0	0	0	1	1	1	6	18	31	21	25	126
	MER + QPX at 4 μg/ml	116	43	28	15	8	7	5	1	1	2	2	2
	MER + QPX at 8 μg/ml	154	31	29	9	3	2	2	0	0	0	0	0
Non-K. pneumoniae KPC (53)	MER	1	0	0	1	2	2	8	12	12	7	4	4
	MER + QPX at 4 μg/ml	47	0	2	2	1	0	0	1	0	0	0	0
	MER + QPX at 8 μg/ml	47	1	2	2	1	0	0	0	0	0	0	0
OXA-48 (39)	MER	0	0	0	1	0	2	2	5	13	11	4	1
	MER + QPX at 4 μg/ml	19	14	5	0	1	0	0	0	0	0	0	0
	MER + QPX at 8 μg/ml	23	11	5	0	0	0	0	0	0	0	0	0
Non-CP-CRE (50)	MER	0	0	0	0	1	5	10	13	12	9	0	0
	MER + QPX 4 μg/ml	5	4	7	10	4	3	6	7	4	0	0	0
	MER + QPX at 8 μg/ml	9	4	13	14	9	1	0	0	0	0	0	0
MBL (224)	MER	2	0	0	1	5	7	20	30	33	30	52	44
	MER + QPX at 4 μg/ml	119	30	18	12	4	11	12	8	3	2	4	1
	MER + QPX at 8 μg/ml	162	13	12	7	9	11	4	2	2	2	0	0
NDM (151)	MER	2	0	0	0	4	5	13	12	19	20	42	34
	MER + QPX at 4 μg/ml	79	25	14	7	1	2	10	5	3	2	2	1
	MER + QPX at 8 μg/ml	113	8	4	2	7	10	2	2	2	1	0	0
VIM (53)	MER	0	0	0	1	1	2	3	14	6	9	7	10
	MER + QPX at 4 μg/ml	32	3	4	3	2	6	1	1	0	0	1	0
	MER + QPX at 8 μg/ml	36	4	6	4	2	0	1	0	0	0	0	0
IMP (20)	MER	0	0	0	0	0	0	4	4	8	1	3	0
	MER + QPX at 4 μg/ml	8	2	0	2	1	3	1	2	0	0	1	0
	MER + QPX at 8 μg/ml	13	1	2	1	0	1	1	0	0	1	0	0

^aMode MIS is in bold.