Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Kinetic parameters of BlaMab inhibition by relebactam (REL) and avibactam (AVI)
| Compound | Ki app (μM) | k2/K (M−1 s−1) | Koff (s−1) | t1/2 (min)a | Kd (nM)b | kcat/kinact |
|---|---|---|---|---|---|---|
| REL | 136 ± 14 | 6.0 × 102 ± 0.6 × 102 | 1.0 × 10−3 ± 0.1 × 10−3 | 11.6 ± 1.2 | 1.7 × 103 ± 0.2 × 103 | 3 |
| AVI | 0.30 ± 0.03 | 3.4 × 105 ± 0.4 × 105 | 2.0 × 10−3 ± 0.2 × 10−3 | 6.0 ± 0.6 | 6 ± 0.6 | 1 |
Residence time half-life (ln2/koff).
Kd = Koff/(k2/K).
