. 2017 Jan 31;76(2):70–88. doi: 10.1093/jnen/nlw109

TABLE 3.

Linear Regression Between Immunohistological Tau Alterations and Insoluble and Soluble Tau With Antemortem Cognitive Evaluation.

Neuropathological markers		Global cognitive score		Episodic memory		Semantic memory		Working memory		Perceptual speed		Visuospatial ability		MMSE
		r ²	p	r ²	p	r ²	p	r ²	p	r ²	p	r ²	p	r ²	p
Tangle counts		−0.494	<0.0001	−0.447	0.0002	−0.446	0.0005	−0.357	0.0067	−0.426	0.0015	−0.422	0.0095	−0.480	<0.0001
Total tau (tau-13)	FA	−0.385	0.0019^*	−0.414	0.0006^*	−0.354	0.0059	0.244	ns	0.261	ns	0.338	ns	−0.325	0.0036^*
	SK	−0.365	0.0031^*	−0.440	0.0003^*	0.240	ns	−0.276	0.0464	0.232	ns	0.313	ns	−0.255	0.0181^*
	TBS	0.141	ns	0.115	ns	0.161	ns	0.171	ns	0.249	ns	0.329	ns	0.106	ns
pS396/404 tau (PHF1)	FA	−0.394	0.0014^*	−0.420	0.0005^*	−0.349	0.0067^*	−0.327	0.0138^*	0.244	ns	0.310	ns	−0.344	0.0022^*
	SK	−0.485	0.0001^*	−0.506	<0.0001^*	−0.355	0.0058^*	−0.342	0.0096^*	−0.368	0.0067	−0.391	0.0213	−0.439	0.0002^*
	TBS	−0.314	0.0427	−0.339	0.0275	0.261	ns	0.265	ns	0.148	ns	0.186	ns	0.269	ns
pT231/S235 tau (AT180)	FA	−0.463	0.0003^*	−0.379	0.002^*	−0.486	0.0002^*	−0.348	0.0060^*	−0.415	0.0040^*	−0.446	0.0072^*	−0.443	0.0003^*
	SK	−0.422	0.0007^*	−0.415	0.0006^*	−0.318	0.0141^*	−0.319	0.0166^*	−0.356	0.0092^*	−0.379	0.0303^*	−0.354	0.0018^*
	TBS	−0.281	0.0219	−0.229	0.0469	−0.281	0.0338	−0.280	0.0421	0.223	ns	−0.377	0.0316	0.186	ns
S196/S198/S199/S202 Up-tau (tau1)	FA	0.200	ns	0.191	ns	0.208	ns	0.272	ns	0.183	ns	0.274	ns	0.161	ns
	SK	−0.276	0.0250	−0.344	0.0044	0.180	ns	0.019	ns	0.248	ns	0.344	ns	−0.222	0.0386
	TBS	0.146	ns	0.190	ns	0.157	ns	0.165	ns	0.167	ns	0.287	ns	0.127	ns

Linear regressions are adjusted by age of death, educational level, gender and APOE genotype. FA, formic acid; MMSE, Mini-Mental State Examination; SK, sarkosyl; TBS, tris-buffered saline; Up-tau, unphosphorylated tau.

Comparable correlations for FA and SK extracted samples.