TABLE 5.

Linear Regression Between Immunohistological TDP43 Alterations and Other Known Markers With Antemortem Cognitive Evaluation.

	Neuropathological markers	Global cognitive score		Episodic memory		Semantic memory		Working memory		Perceptual speed		Visuospatial ability		MMSE
		r 2	p	r 2	p	r 2	p	r 2	p	r 2	p	r 2	p	r 2	p
Synaptic markers	Synaptophysin	0.335	0.0066	0.259	0.023	0.307	0.0202	0.315	0.0344	0.327	0.0213	0.395	0.0250	0.205	ns
	Septin-3	0.257	0.0254	0.190	0.0431	0.286	ns	0.305	0.0255	0.242	ns	0.302	ns	0.193	0.0475
	SNAP25	0.190	ns	0.124	ns	0.283	0.0325	0.210	ns	0.248	ns	0.357	ns	0.133	ns
	Drebrin	0.141	ns	0.118	ns	0.158	ns	0.179	ns	0.197	ns	0.271	ns	0.105	ns
	Syntaxin 3	0.132	ns	0.110	ns	0.200	ns	0.186	ns	0.165	ns	0.321	ns	0.075	ns
	PSD-95	0.160	ns	0.155	ns	0.162	ns	0.171	ns	0.242	ns	0.268	ns	0.128	ns
Cholinergic markers	ChAT	0.155	ns	0.151	ns	0.152	ns	0.134	ns	0.207	ns	0.275	ns	0.119	ns
	VAChT	0.137	ns	0.132	ns	0.179	ns	0.168	ns	0.193	ns	0.276	ns	0.100	ns
Other markers	VILIP-1	0.190	ns	0.128	ns	0.213	ns	0.312	0.0218	0.194	ns	0.343	ns	0.118	ns
	GSTP1	−0.254	0.0407	−0.241	0.0364	−0.247	ns	−0.231	ns	−0.238	ns	−0.278	ns	−0.175	ns
	Cytoplasmic pS403/404 TDP-43 inclusions	−0.476	0.0015	−0.43	0.0055	−0.324	0.0276	−0.363	0.0173	−0.544	0.0005	−0.630	0.0004	−0.513	0.0004
	pS403/404 TDP-43	0.265	0.0316	0.296	0.0105	0.188	ns	0.244	ns	0.203	ns	0.308	ns	0.150	ns
	SIRT1	0.179	ns	0.152	ns	0.219	ns	0.180	ns	0.253	ns	0.279	ns	0.085	ns
	PAK1/2/3	0.239	ns	0.219	ns	0.209	ns	0.219	ns	0.287	0.0463	0.365	0.0348	0.159	ns

Linear regressions are adjusted by age of death, educational level, gender and APOE genotype. TDP-43 data used for this linear regression analysis were previously published [104]. ChAT, choline acetyltransferase; VAChT, vesicular acetylcholine transporter; VILIP-1, visinin-like protein-1; GSTP1, glutathione S-transferase P-1; TDP-43, transactive response DNA binding protein 43; SIRT1, sirtuin 1; PAK, p21-activated kinase; SNAP-25, synaptosomal-associated protein 25 kDa; PSD-95, postsynaptic density protein 95.