TABLE 6.

Linear Regression Analysis Between Synaptic Markers, TDP-43 and Markers of Amyloid and Tau Pathologies in the Parietal Cortex.

	Neuropathological Markers	Plaque count		Insoluble Aβ42		Tangle count		Insoluble total tau (tau13)		Insoluble pS396/404 tau (PHF1)		Insoluble pT231/S235 tau (AT180)
		r²	p	r²	p	p	p	r²	p	r²	p	r²	p
Synaptic markers	Synaptophysin	0.132	ns	0.083	ns	0.085	ns	0.310	ns	0.159	ns	0.134	ns
	Septin-3	0.170	ns	0.060	ns	0.138	ns	0.282	ns	0.194	ns	0.209	ns
	SNAP25	0130	ns	0.104	ns	0.089	ns	0.261	ns	0.130	ns	0.156	ns
	drebrin	0.132	ns	0.089	ns	0.073	ns	0.260	ns	0.167	ns	0.107	ns
	Syntaxin 3	0.123	ns	0.135	ns	0.077	ns	0.347	ns	0.171	ns	0.109	ns
	PSD-95	0.190	ns	0.089	ns	0.115	ns	0.296	ns	0.236	ns	0.148	ns
Cholinergic markers	ChAT	-0.281	0.0276	0.186	ns	0.097	ns	0.279	ns	-0.303	0.0123	0.127	ns
	VAChT	0.184	ns	0.088	ns	0.127	ns	0.285	ns	-0.271	0.0224	0.133	ns
Others markers	VILIP-1	0.148	ns	0.114	ns	0.087	ns	0.258	ns	0.147	ns	0.105	ns
	GSTP1	0.249	0.0343	0.181	ns	0.095	ns	0.342	0.0520	0.191	ns	0.124	ns
	Cytoplasmic pS403/404 TDP-43 inclusions	0.463	0.0138	0.198	ns	0.369	0.0168	0.219	ns	0.160	ns	0.358	0.0155
	pS403/404 TDP-43	0.225	ns	0.191	ns	0.076	ns	0.304	ns	0.253	0.0339	0.107	ns
	SIRT1	0.204	ns	0.148	ns	0.195	ns	0.258	ns	0.170	ns	0.147	ns
	PAK1/2/3	0.216	ns	0.174	ns	-0.293	0.0068	-0.392	0.0560	-0.258	0.0576	-0.374	0.0023

Linear regressions are adjusted by age of death, educational level, gender and APOE genotype. TDP-43 data’s used for these linear regression analysis were previously published [104]. Abbreviations: ChAT, choline acetyltransferase; VAChT, vesicular acetylcholine transporter; VILIP-1, visinin-like protein-1; GSTP1, glutathione S-transferase P-1; TDP-43, transactive response DNA binding protein 43; SIRT1, sirtuin 1; PAK, p21-activated kinase; SNAP-25, synaptosomal-associated protein 25kDa; PSD-95, postsynaptic density protein 95.