FIGURE 3.

GW0742 attenuates amyloid beta-induced suppression of long-term potentiation (LTP) in ex vivo hippocampal synapses. Hippocampal slices (400 μm) from 3 to 4 months old male C57BL/6J wild type (wt) mice were exposed to 1 μM oligomeric amyloid beta (Aβ) 1–42 to mimic AD-conditions and treated with vehicle or 10 μM GW0742. (a) The electrophysiology recording was started 30 min before high-frequency stimulation (HFS: 1 s burst pulse at 100 Hz) at 0 min, and alterations of LTP were measured for 60 min. LTP presented as percentage of increase in slope of fEPSP normalized to baseline. (b) The quantitative analysis of LTP 60 min after HFS. All data are presented as mean ± SEM with **p < .01. (veh n = 6, GW42 n = 10, Aβ n = 7, Aβ GW42 n = 10)