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. Author manuscript; available in PMC: 2021 Sep 17.
Published in final edited form as: Tetrahedron Lett. 2020 Aug 16;61(38):152353. doi: 10.1016/j.tetlet.2020.152353

Scheme 2:

Scheme 2:

Initial synthetic route to the furo[2,3-b]pyridine core 15. i) EtOH, H2SO4, 80 °C‚ 16 h, 95%. ii) 1.1 eq. 13, 3.5 eq. NaH, THF, 0–70 °C, 3 h, 88%. iii) 3 eq. KOH, EtOH, 100 °C, 20 min then aq. HCl, 100 °C, 20 min, 0%.