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. Author manuscript; available in PMC: 2020 Sep 30.
Published in final edited form as: Addict Biol. 2019 Feb 27;25(1):e12741. doi: 10.1111/adb.12741

FIGURE 6.

FIGURE 6

Receiver-operating-characteristic (ROC) curve of the weighted genetic risk score (wGRS) (dashed line) in discriminating CYP2A6 slow and fast metabolizer groups using an NMR cut-point of 0.31 in the replication cohort. The wGRS for an nicotine metabolite ratio (NMR) cut-point of 0.31 (slow: NMR < 0.31, normal: NMR ≥ 0.31)12 yielded an area under the curve (AUC) estimate of 0.78; P < 0.001 (95% confidence interval (CI), 0.71–0.85). The wGRS for an NMR cut-point of 0.26 (slow: NMR < 0.26, normal: NMR ≥ 0.26)13 yielded an AUC estimate of 0.78; P < 0.001 (95% CI, 0.71–0.86) (not shown)