FIG 5.

A very broad and diverse TCR repertoire is maintained during and after an acute viral infection. (a) Longitudinal assessment of serum viral titer in acute LCMV Armstrong (cartoon illustration based on historical data [30, 50, 58]) and chronic LCMV Cl-13 (n = 15) infection models. (b) Six individual mice were sacrificed to analyze TCR frequency distribution of GP33-specific clonotypes 8 days (effector phase) and 7 months (memory phase) after an acute infection. Each color indicates the same TCR clonotype only within an individual mouse. (c) The Morisita-Horn (M-H) index was used to quantify the clonal overlap between mice. (d) Cross-sectional comparison of clonotype numbers between different time points. (e) Cross-sectional comparison of clonality measurements between different time points. Shown are the mean and SD from experiments with 3 mice. ns, nonsignificant (determined using Student's t test).