TABLE 3.
MN titers changes of H7 viruses with either L226 or Q226 in responding to immune sera
|
Virus tested |
H7/AH13 immune sera |
H7/GD16 immune sera |
||||||
|---|---|---|---|---|---|---|---|---|
| Mouse |
Macaque |
Mouse |
Macaque |
|||||
| MN titera | Fold changeb | MN titera | Fold changeb | MN titera | Fold changeb | MN titera | Fold changeb | |
| H7/AH13 | 640 | 1,280 | 853 | 427 | ||||
| H7/AH13/L226Q | 693 | 1.1 | 1,280 | 1.0 | 1,280 | 1.5 | 533 | 1.2 |
| H7/GD16 | 533 | 0.8 | 1,067 | 0.8 | 1,706 | 2 | 853 | 2 |
| H7/GD16/Q226L | 853 | 1.3 | 1,493 | 1.2 | 1,493 | 1.8 | 533 | 1.2 |
a
MN assays were carried out using immune sera from mice or rhesus macaques 4 weeks after the second immunization. Data are representative values from three independent assays.
b
Observed fold change in MN titer compared with H7/AH13.