FIG 1.

PRVABC59 is attenuated in Ifnar1^−/− mice. Five- to six-week-old Ifnar1^−/−, Ifnar1^−/− Ifngr1^−/− DKO, or Ifng^−/− mice were inoculated with 1 × 10³ (A to D) or 1 × 10⁵ (E and F) FFU of ZIKV strain PRVABC59 or H/PF/2013 isolate viruses by a subcutaneous route. Mice were weighed daily for 14 days, and weights are expressed as percentages of body weight prior to infection and were censored once one mouse in a group died. Results shown are the mean values ± standard errors of the means (SEM) for the indicated number of mice from one (E and F) or two (A to D) independent experiments. Lethality was monitored for 21 days. †, the mouse died at 20 dpi.