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. 2020 Jun 9;11(5):1385–1404. doi: 10.1080/19490976.2020.1758290

Figure 2.

Figure 2.

Effect of PPI and Bifidobacterium bifidum G9-1 in the mouse model of ASA-induced injury. Male C57BL/6JJcl mice (2–4) were housed in each cage. (a) Relative abundance of Bifidobacteria in human fecal samples (n = 19) before and after omeprazole treatment. (b) Protocol for the mouse model. Sixty percent of fructose diets were fed to six-week-old mice for 9 weeks. Mice were divided into five treatment groups. Omeprazole or vehicle was administered intraperitoneally once daily. G9-1 or vehicle was administered orally for 1 week before sacrifice. On the last day, ASA or vehicle was administered orally 3 h before sacrifice. (c) HE staining of the jejunum. Scale bars = 100 μm. (d) Histopathological scores for small intestine injury. (n = 8–11 per group). (e) Levels of serum endotoxin at the end of the experiment (n = 5–8 per group). (f) Small intestinal permeability at five, seven, and nine weeks (n = 5–8 per group). Data are means ± SEM. *p < .05, **p < .01, Wilcoxon signed-sum test (a), Steel-Dwass test (d), or Tukey–Kramer test (e, f).