Fig. 1.

Citrullinated histone H3 is elevated in septic patients. a Citrullinated histone H3 in healthy volunteers, non-infections disease controls and septic patients at the enrollment in the emergency department. Citrullinated histone H3 was higher in septic patients than healthy volunteers and non-infections disease controls. b Citrullinated histone H3 levels in septic patients over time. Citrullinated histone H3 increased during the first 24 h but not 48 h. Data are presented as median value (line in box), interquartile range (box) and 90% (whiskers). Kruskal–Wallis test followed by Dunn’s multiple comparison test was performed for difference analyses. Linear mixed effects regression was further analyzed in Fig. 1b. *p < 0.05, ****p < 0.001. HV healthy volunteers, NIC non-infections disease controls, SP septic patients, CitH3 Citrullinated histone H3