Fig. 3.

Citrullinated histone H3 is a potential prognostic marker in advanced sepsis. a Citrullinated histone H3 levels in sepsis 90d survivor and non-survivor groups at enrollment (0 h), 24 h and 48 h. Levels of citrullinated histone H3 were significantly elevated in the non-survivor group than survivor group at 24 h and 48 h, not at the enrollment (0 h). Data are presented as median value (line in box), interquartile range (box) and 90% (whiskers). b Receiver operating characteristic curves of citrullinated histone H3 to discriminate between survivors and non-survivors at enrollment, 24 h and 48 h. The receiver operating characteristic curve analysis of citrullinated histone H3 is presented in the separate table next to the figure. The area under the receiver operating characteristic curves are **p < 0.01 and *p < 0.05 at 24 h and 48 h, and p > 0.05 at enrollment (0 h). ROC receiver operating characteristic curve, Sen sensitivity, Spe specificity, PPV positive predictive value, NPV negative predictive value; CitH3 citrullinated histone H3