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. Author manuscript; available in PMC: 2021 Sep 8.
Published in final edited form as: Circ Heart Fail. 2020 Sep 8;13(9):e006910. doi: 10.1161/CIRCHEARTFAILURE.120.006910

Table 2.

Hazard Ratio Estimates for LVAD Outcomes by Psychosocial Risk

LVAD Outcomes Unadjusted Cox Regression Adjusted Cox Regression*
HR (95% CI) p-value HR (95% CI) p-value
Survival on pump support
Any Psychosocial Risk 0.84 (0.77 – 0.92) <0.001 0.99 (0.91 – 1.09) 0.902
Limited Social Support 0.90 (0.77 – 1.05) 0.182 0.96 (0.81 – 1.13) 0.608
Limited Cognition 0.81 (0.63 – 1.05) 0.107 0.84 (0.64 – 1.11) 0.213
Substance Abuse
 ETOH Abuse 0.82 (0.72 – 0.93) 0.002 0.96 (0.84 – 1.10) 0.533
 Drug Use 0.68 (0.59 – 0.79) <0.001 0.97 (0.83 – 1.14) 0.703
Psychiatric Disease
 Severe Depression 0.89 (0.72 – 1.10) 0.272 0.95 (0.76 – 1.19) 0.653
 Other Major Psychiatric Dx 1.08 (0.85 – 1.37) 0.529 1.38 (1.07 – 1.77) 0.012
Non-Compliance 0.94 (0.78 – 1.13) 0.515 1.16 (0.95 – 1.40) 0.137
Cardiac Transplantation
Any Psychosocial Risk 0.82 (0.76 – 0.90) <0.001 0.85 (0.80 – 0.91) <0.001
Limited Social Support 0.68 (0.57 – 0.81) <0.001 0.82 (0.68 – 0.99) 0.038
Limited Cognition 0.67 (0.51 – 0.89) 0.005 0.66 (0.49 – 0.89) 0.006
Substance Abuse
 ETOH Abuse 0.93 (0.83 – 1.05) 0.249 0.88 (0.77 – 0.99) 0.041
 Drug Use 0.95 (0.84 – 1.07) 0.392 0.84 (0.74 – 0.96) 0.011
Psychiatric Disease
 Severe Depression 0.82 (0.66 – 1.01) 0.066 0.81 (0.64 – 1.02) 0.068
 Other Major Psychiatric Dx 1.12 (0.88 – 1.41) 0.357 1.10 (0.86 – 1.41) 0.444
Non-Compliance 0.62 (0.50 – 0.78) <0.001 0.68 (0.54 – 0.86) 0.001
Device Related Infection
Any Psychosocial Risk 1.40 (1.28 – 1.54) <0.001 1.29 (1.17 – 1.43) <0.001
Limited Social Support 1.57 (1.35 – 1.84) <0.001 1.44 (1.22 – 1.69) <0.001
Limited Cognition 1.22 (0.94 – 1.59) 0.132 1.22 (0.92 – 1.61) 0.161
Substance Abuse
 ETOH Abuse 1.30 (1.14 – 1.49) <0.001 1.26 (1.09 – 1.45) 0.002
 Drug Use 1.43 (1.25 – 1.63) <0.001 1.24 (1.07 – 1.44) 0.004
Psychiatric Disease
 Severe Depression 1.22 (0.97 – 1.53) 0.083 1.12 (0.88 – 1.42) 0.345
 Other Major Psychiatric Dx 1.62 (1.26 – 2.08) <0.001 1.46 (1.12 – 1.90) 0.006
Non-Compliance 1.58 (1.31 – 1.90) <0.001 1.37 (1.13 – 1.67) 0.002
Gastrointestinal Bleeding
Any Psychosocial Risk 0.98 (0.90 – 1.06) 0.532 1.20 (1.11 – 1.31) <0.001
Limited Social Support 0.96 (0.82 – 1.11) 0.555 1.06 (0.91 – 1.24) 0.467
Limited Cognition 1.13 (0.91 – 1.05) 0.267 1.24 (0.99 – 1.56) 0.058
Substance Abuse
 ETOH Abuse 1.02 (0.90 – 1.14) 0.794 1.22 (1.08 – 1.38) 0.002
 Drug Use 0.74 (0.65 – 0.85) <0.001 1.08 (0.93 – 1.24) 0.325
Psychiatric Disease
 Severe Depression 1.08 (0.89 – 1.30) 0.432 1.26 (1.03 – 1.53) 0.023
 Other Major Psychiatric Dx 0.88 (0.68 – 1.13) 0.319 1.17 (0.90 – 1.53) 0.223
Non-Compliance 1.10 (0.93 – 1.31) 0.250 1.40 (1.17 – 1.67) <0.001
Device Thrombosis (Suspected or Confirmed)
Any Psychosocial Risk 1.27 (1.14 – 1.41) <0.001 1.19 (1.06 – 1.33) 0.002
Limited Social Support 1.27 (1.05 – 1.53) 0.013 1.19 (0.98 – 1.45) 0.087
Limited Cognition 1.10 (0.81 – 1.50) 0.544 1.06 (0.77 – 1.47) 0.723
Substance Abuse
 ETOH Abuse 1.05 (0.89 – 1.24) 0.539 1.08 (0.91 – 1.29) 0.363
 Drug Use 1.37 (1.18 – 1.60) <0.001 1.19 (1.01 – 1.41) 0.038
Psychiatric Disease
 Severe Depression 1.40 (1.10 – 1.77) 0.006 1.27 (0.99 – 1.63) 0.061
 Other Major Psychiatric Dx 1.57 (1.19 – 2.07) 0.002 1.37 (1.01 – 1.85) 0.042
Non-Compliance 1.43 (1.16 – 1.77) <0.001 1.29 (1.03 – 1.62) 0.024
Stroke (Ischemic or Hemorrhagic)
Any Psychosocial Risk 1.02 (0.92 – 1.12) 0.765 1.11 (0.99 – 1.24) 0.067
Limited Social Support 0.97 (0.80 – 1.17) 0.726 0.98 (0.80 – 1.20) 0.846
Limited Cognition 1.00 (0.75 – 1.35) 0.959 0.96 (0.70 – 1.32) 0.788
Substance Abuse
 ETOH Abuse 1.01 (0.87 – 1.18) 0.853 1.15 (0.98 – 1.35) 0.084
 Drug Use 0.89 (0.76 – 1.05) 0.169 1.00 (0.84 – 1.19) 0.976
Psychiatric Disease
 Severe Depression 0.88 (0.67 – 1.15) 0.349 0.89 (0.67 – 1.18) 0.420
 Other Major Psychiatric Dx 1.12 (0.83 – 1.51) 0.467 1.15 (0.84 – 1.59) 0.380
Non-Compliance 1.28 (1.04 – 1.56) 0.018 1.38 (1.11 – 1.71) 0.004
Hospital Readmission
Any Psychosocial Risk 1.08 (1.03 – 1.13) 0.002 1.14 (1.08 – 1.19) <0.001
Limited Social Support 1.06 (0.98 – 1.15) 0.169 1.13 (1.04 – 1.24) 0.005
Limited Cognition 1.00 (0.87 – 1.14) 0.948 1.09 (0.94 – 1.26) 0.263
Substance Abuse
 ETOH Abuse 1.06 (0.99 – 1.14) 0.071 1.11 (1.03 – 1.19) 0.005
 Drug Use 1.03 (0.96 – 1.11) 0.373 1.09 (1.01 – 1.17) 0.022
Psychiatric Disease
 Severe Depression 1.20 (1.07 – 1.33) 0.001 1.18 (1.06 – 1.33) 0.004
 Other Major Psychiatric Dx 1.42 (1.25 – 1.62) <0.001 1.40 (1.22 – 1.60) <0.001
Non-Compliance 1.04 (0.94 – 1.15) 0.439 1.10 (0.99 – 1.22) 0.085

ETOH = alcohol

*

Adjusted for age, gender, race, BSA, implant year, HF etiology, RVAD use, pump type (axial vs. centrifugal), INTERMACS Class, device strategy (destination vs. bridge), creatinine, bilirubin, and albumin levels.