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. Author manuscript; available in PMC: 2021 Sep 8.
Published in final edited form as: Circ Heart Fail. 2020 Sep 8;13(9):e006910. doi: 10.1161/CIRCHEARTFAILURE.120.006910

Table 3.

Additive Impact of Psychosocial Risk Factors on LVAD Outcomes

LVAD Outcomes Unadjusted Cox Regression Adjusted Cox Regression*
HR (95% CI) p-value HR (95% CI) p-value
Survival on pump support
0 Psychosocial Risk Factor
1 Psychosocial Risk Factor 0.87 (0.79 – 0.96) 0.004 1.01 (0.91 – 1.12) 0.842
2+ Psychosocial Risk Factors 0.76 (0.64 – 0.89) 0.001 0.94 (0.79 – 1.12) 0.495
Cardiac Transplantation
0 Psychosocial Risk Factor
1 Psychosocial Risk Factor 0.87 (0.79 – 0.95) 0.002 0.86 (0.78 – 0.95) 0.003
2+ Psychosocial Risk Factors 0.70 (0.59 – 0.82) <0.001 0.72 (0.60 – 0.86) <0.001
Device Related Infection
0 Psychosocial Risk Factor
1 Psychosocial Risk Factor 1.31 (1.18 – 1.46) <0.001 1.23 (1.10 – 1.37) <0.001
2+ Psychosocial Risk Factors 1.40 (1.28 – 1.54) <0.001 1.49 (1.27 – 1.76) <0.001
Gastrointestinal Bleeding
0 Psychosocial Risk Factor
1 Psychosocial Risk Factor 0.97 (0.89 – 1.06) 0.546 1.18 (1.07 – 1.29) 0.001
2+ Psychosocial Risk Factors 0.98 (0.85 – 1.14) 0.803 1.29 (1.11 – 1.51) 0.001
Device Thrombosis (Suspected or Confirmed)
0 Psychosocial Risk Factor
1 Psychosocial Risk Factor 1.21 (1.07 – 1.36) 0.002 1.15 (1.01 – 1.31) 0.031
2+ Psychosocial Risk Factors 1.47 (1.23 – 1.76) <0.001 1.32 (1.09 – 1.59) 0.005
Stroke (Ischemic or Hemorrhagic)
0 Psychosocial Risk Factor
1 Psychosocial Risk Factor 1.03 (0.92 – 1.15) 0.656 1.12 (1.00 – 1.27) 0.059
2+ Psychosocial Risk Factors 0.98 (0.81 – 1.19) 0.864 1.06 (0.86 – 1.30) 0.585
Hospital Readmission
0 Psychosocial Risk Factor
1 Psychosocial Risk Factor 1.06 (1.00 – 1.12) 0.022 1.12 (1.06 – 1.18) <0.001
2+ Psychosocial Risk Factors 1.12 (1.03 – 1.22) 0.006 1.21 (1.11 – 1.32) <0.001