Table 3.

Additive Impact of Psychosocial Risk Factors on LVAD Outcomes

LVAD Outcomes	Unadjusted Cox Regression		Adjusted Cox Regression*
	HR (95% CI)	p-value	HR (95% CI)	p-value
Survival on pump support
0 Psychosocial Risk Factor	…	…	…	…
1 Psychosocial Risk Factor	0.87 (0.79 – 0.96)	0.004	1.01 (0.91 – 1.12)	0.842
2+ Psychosocial Risk Factors	0.76 (0.64 – 0.89)	0.001	0.94 (0.79 – 1.12)	0.495
Cardiac Transplantation
0 Psychosocial Risk Factor	…	…	…	…
1 Psychosocial Risk Factor	0.87 (0.79 – 0.95)	0.002	0.86 (0.78 – 0.95)	0.003
2+ Psychosocial Risk Factors	0.70 (0.59 – 0.82)	<0.001	0.72 (0.60 – 0.86)	<0.001
Device Related Infection
0 Psychosocial Risk Factor	…	…	…	…
1 Psychosocial Risk Factor	1.31 (1.18 – 1.46)	<0.001	1.23 (1.10 – 1.37)	<0.001
2+ Psychosocial Risk Factors	1.40 (1.28 – 1.54)	<0.001	1.49 (1.27 – 1.76)	<0.001
Gastrointestinal Bleeding
0 Psychosocial Risk Factor	…	…	…	…
1 Psychosocial Risk Factor	0.97 (0.89 – 1.06)	0.546	1.18 (1.07 – 1.29)	0.001
2+ Psychosocial Risk Factors	0.98 (0.85 – 1.14)	0.803	1.29 (1.11 – 1.51)	0.001
Device Thrombosis (Suspected or Confirmed)
0 Psychosocial Risk Factor	…	…	…	…
1 Psychosocial Risk Factor	1.21 (1.07 – 1.36)	0.002	1.15 (1.01 – 1.31)	0.031
2+ Psychosocial Risk Factors	1.47 (1.23 – 1.76)	<0.001	1.32 (1.09 – 1.59)	0.005
Stroke (Ischemic or Hemorrhagic)
0 Psychosocial Risk Factor	…	…	…	…
1 Psychosocial Risk Factor	1.03 (0.92 – 1.15)	0.656	1.12 (1.00 – 1.27)	0.059
2+ Psychosocial Risk Factors	0.98 (0.81 – 1.19)	0.864	1.06 (0.86 – 1.30)	0.585
Hospital Readmission
0 Psychosocial Risk Factor	…	…	…	…
1 Psychosocial Risk Factor	1.06 (1.00 – 1.12)	0.022	1.12 (1.06 – 1.18)	<0.001
2+ Psychosocial Risk Factors	1.12 (1.03 – 1.22)	0.006	1.21 (1.11 – 1.32)	<0.001