Figure 2. Simulations of retino- and cortico-collicular mapping in Isl2-Epha3KI animals.

(A, G, M) Representation of measured retinal Epha gradients along the nasal-temporal (NT) axis in WT (A), Isl2^Epha3/+ (G) and Isl2^Epha3/Epha3 (M) animals (see Materials and methods and Table 1 for equations). (B, H, N) Representation of the estimated collicular Efna gradients along the rostral-caudal (RC) axis in WT (B), Isl2^Epha3/+ (H) and Isl2^Epha3/Epha3 (N) animals (see Materials and methods and Table 1 for equations). (C, I, O) Representation of the transposed retinal Efna gradients into the SC along the RC axis in WT (C), Isl2^Epha3/+ (I) and Isl2^Epha3/Epha3 (O) animals (see Materials and methods and Table 1 for equations). (D, J, P) Representation of the estimated cortical Epha gradients along the medial-lateral (ML) axis in V1 in WT (D), Isl2^Epha3/+ (J) and Isl2^Epha3/Epha3 (P) animals (see Materials and methods and Table 1 for equations). (E, K, Q) Simulated RC map in in WT (E), Isl2^Epha3/+ (K) and Isl2^Epha3/Epha3 (Q) animals generated by the 3-step map alignment algorithm (representative of n = 20 runs). (F, L, R) Simulated cortico-collicular map in WT (F), Isl2^Epha3/+ (L) and Isl2^Epha3/Epha3 (R) animals generated by the 3-step map alignment algorithm (representative of n = 20 runs). Abbreviations: N, nasal; T, temporal; R, rostral; C, caudal; M, medial; L, lateral.