Table 2.
Clinical characteristics of patients with Scedosporium spp. positive and negative sputum samples.
| Scedosporium spp. positive N = 94 | Scedosporium spp. negative N = 1218 | ||
|---|---|---|---|
| n (%) | n (%) | P-valuea | |
| Demographic factors | |||
| Age, years (mean, SD) | 22 (12) | 21 (15) | 0.345 |
| Sex, female | 53 (56) | 575 (47) | 0.088 |
| BMI, (mean, SD) | 20 (3) | 20 (4) | 0.173 |
| Genotype, severe CFTR mutationsb | 83 (89) | 949 (78) | 0.010 |
| Disease characteristics | |||
| CF-related diabetes | 30 (33) | 232 (20) | 0.003 |
| ABPA | 14 (15) | 105 (9) | 0.049 |
| Lung function, FEV1 (mean, SD) | 71 (23) | 71 (25) | 0.950 |
| Microorganisms | |||
| Pseudomonas aeruginosa | 43 (47) | 387 (35) | 0.020 |
| Stenotrophomonas maltophilia | 16 (17) | 85 (8) | 0.001 |
| Staphylococcus aureus | 43 (47) | 369 (33) | 0.007 |
| Burkholderia cepacia | 2 (2) | 21 (2) | 0.692 |
| Nontuberculous mycobacteria | 3 (3) | 15 (1) | 0.150 |
| Aspergillus spp. | 47 (51) | 283 (26) | <0.001 |
| Medications | |||
| Inhalation corticosteroids | 32 (36) | 315 (31) | 0.370 |
| Azithromycin | 50 (56) | 485 (46) | 0.071 |
| Inhalation antibiotics | 48 (52) | 447 (39) | 0.012 |
a
T-test for continuous variables, Chi-2 for binary variables and Fisher's exact for binary variables with less than 10 cases.
b
Severe mutations was defined as 2 CFTR mutations from class I-III.
ABPA, allergic bronchopulmonary aspergillosis; BMI, body mass index; CF, cystic fibrosis; CFTR, cystic fibrosis transmembrane conductance regulator; FEV1,. forced expiratory volume in 1 second.